Primary dural-based MALT lymphoma mimicking falx meningioma: a case report
Keywords:
MALT, marginal zone lymphoma, central nervous system, dura mater, MRI, case reportAbstract
Abstract
Introduction
Primary dural lymphoma (PDL) is very rare and often misdiagnosed as meningioma based on neuroimaging characteristics.
Case report
A 36-year-old woman presented with headache, behaviour changes and ataxia. She had no history of oncology or immunodeficiency. Magnetic resonance imaging showed a solitary mass lesion in the anterior and middle thirds of the falx cerebri with bilateral growth and a moderate mass effect, which was interpreted as a falx meningioma. Gross total resection of the lesion involving the dura mater of the falx cerebri was performed by bilateral parasagittal craniotomy. Surprisingly, histological examination showed no meningothelial components. Instead, there was diffuse lymphocytic and plasma cell infiltration. Immunohistochemistry was positive for B-cell antigens. The final histopathological diagnosis was primary dural mucosa-associated lymphoid tissue lymphoma. Systemic screening examination was then performed and did not reveal additional tumor foci or lymphadenopathy. Follow-up brain MRI at 3 months did not reveal tumor progression. Neither chemotherapy nor radiotherapy were given, and the patient is under observation.
Conclusion
Diagnostic errors can cause delays in pathogenetic treatment of primary dural lymphoma. Thus, PDL should be considered in the differential diagnosis of meningiomas.
Keywords: MALT, marginal zone lymphoma, central nervous system, dura mater, MRI, case report
Declarations
Ethics approval and consent to participate
Data acquisition and publication were in accordance with the principles outlined in the Declaration of Helsinki. The local ethics committee (Federal Neurosurgical Center of Novosibirsk Ethics Committee) has confirmed that no ethical approval is needed.
Consent for publication
Written informed consent was taken from the patient. The identity of the patient is not revealed in the pictures or in the manuscript.
Availability of data and material
Data can be provided by the corresponding authors upon request.
Competing interests
The authors declare that they have no competing interests.
Funding
No funding.
Authors’ contributions
OA: acquisition of the data, analysis and research of the literature, and preparation of the manuscript. EF: conception and design of the manuscript, analysis and research of the literature, and preparation of the manuscript. AK: revision of the manuscript. JR: administrative support and supervision. All authors read and approved the final manuscript.
Acknowledgements
None
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